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CHRISTMAS 2020 ❆ BC HOLSTEIN NEWS 45
 Study Finds Vaccine Protocol Drift
 Leaving Calves Scouring Bobbi Brockmann, ImmuCell VP Sales & Marketing
 BBrockmann@immucell.com
A wise person once told me: Don’t leave success to chance. When it comes to herd health, the odds of a good outcome are improved by intentionally understanding and carrying out best management practices guided by defined protocols.
For years, farmers have implemented a dam-level scour vaccination program to help prevent newborn calf scours. Despite these vaccines, incidence of scours has not improved in more than 20 years. To better understand why calves are still getting sick, a leading animal health marketing research firm * completed a survey capturing the deviation level outside of vaccine label requirements. The study represented 100 dairies and 77,154 lactating cows across the USA. Results confirmed that nearly 80% of operations were noncompliant with label requirements, leaving calves unprotected and farmers wasting money.
Vaccine effectiveness depends on many factors, starting with following label instructions. Failure to follow label requirements, also known as protocol drift, is one reason vaccinations aren’t as effective on the farm as they are in a lab. According to the study, about 40% of farmers did not vaccinate all first-calf heifers. Of the heifers vaccinated, more than one-third didn’t receive the second shot required for primary vaccination. The necessary annual booster was missed on nearly 25% of previously vaccinated cows.
Timing of administration also presents challenges, as pre-calving scour vaccines are only effective if given during the timeframe outlined on the label. Farmers reported that more than one-third of first- calf heifers received the required second dose outside the label-required time period pre-calving. In addition, almost two-thirds of farmers administering the annual booster to lactating cows estimated they gave it earlier or later than prescribed. In the survey, farmers reported that 20% of cows calved two or more weeks off the projected calving date, either too early or late. This discrepancy likely puts these cows outside of the critical window needed to maximize scour-preventing antibody concentrations in the colostrum.
A final determination showed that protocol drift occurred at equal rates for both first-calf heifers and pregnant cows, leading to nearly 80% of operations being noncompliant with label requirements directly related to the vaccine’s effectiveness. (See figure.)
Because protocol drift is a constant challenge with vaccination programs, farmers and veterinarians are seeking alternative treatments that deliver specific antibodies at the gut level – without a vaccine. During a recent immunology symposium, Dr. Chris Chase, Department of Veterinary and Biomedical Sciences at South Dakota State University, highlighted the use of preformed antibodies to
immunize newborn calves against scour pathogens. According to the SDSU professor, these antibodies reduce immunization variability, while protecting against both bacterial and viral scours.
* Study reference available on request
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